A NON-ACE2 COMPETING HUMAN SINGLE-DOMAIN ANTIBODY CONFERS BROAD NEUTRALIZATION AGAINST SARS-COV-2 AND CIRCULATING VARIANTS

A non-ACE2 competing human single-domain antibody confers broad neutralization against SARS-CoV-2 and circulating variants

Abstract The current COVID-19 pandemic has heavily burdened the global public health system and may keep simmering for years.The frequent emergence of immune escape variants have spurred the search for prophylactic vaccines and therapeutic antibodies that confer broad protection against SARS-CoV-2 variants.Here we show that the bivalency of an affi

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Familial Adenomatous Polyposis Manifesting as Lactococcus Endocarditis: A Case Report and Review of the Association of Lactococcus with Underlying Gastrointestinal Disease

A 45-year-old male with a prosthetic aortic valve presented to the hospital with several months of generalized malaise.On admission, he was noted to have anemia of unclear etiology and subsequently became febrile with multiple blood cultures growing Lactococcus garvieae.Inpatient workup was concerning for infectious endocarditis (IE) secondary to L

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